In this version, the characters are more mature, played by actual celebrities & the movie is darker.
- Paige O'Hara as Twilight Sparkle: A worker at Barne's & Noble's. She isn't Celestia's student, just her friend. She is killed by Star Swirl but is revived through a deus ex machina.
- Christopher Lee as Star Swirl the Bearded: The founder of Ponyville who tries to kill everyone by twisting time so the blizzard would freeze the world into another Ice Age.
- Isla Fisher as The Great & Powerful Trixie Lulamoon: A magician whose Twilight's best friend. She does like Twilight.
- Minni Driver as Rarity: A fashionista who works at Walmart that Twilight meets her first instead of third. She is killed by Star Swirl but is revived through a deus ex machina.
- Elle Fanning as Fluttershy: A shy girl that works at a animal shelter that Twilight meets her second instead fourth. She is killed by Star Swirl but is revived through a deus ex machina.
- Sarah Michelle Gellar as Rainbow Dash: a sportswoman who works at Dick's Sporting Goods who Twilight meets third instead of second. She is killed by Star Swirl but is revived through a deus ex machina.
- Amy Adams as Pinkie Pie: the manager of Party City who Twilight meets fourth than fifth. She is killed by Star Swirl but is revived through a deus ex machina.
- Christina Applegate as Applejack: a worker at Home Depot who Twilight meets fifth than first. She is killed by Star Swirl but is revied through a deus ex machina.
- Kate Beckinsale as Celestia: The mayor of Ponyville who brings the Main Six together. She is killed by Star Swirl.
- Christina Ricci as Luna/Nightmare Moon: Celestia's sister who was always jealous of her sister. She tried to blacken out the sun using a satellite as Nightmare Moon, but is turned back to normal. She is killed by Star Swirl.
- Christopher Walken as Sombra: a corrupted general who tried to rule Ponyville under martial law.
- Keira Knightley as Cadance: Twilight's former babysitter who Shining Armor goes on dates to. She & Shining Armor help Twilight stop Star Swirl. She later attends Twilight's funeral.
- Brenden Fraser as Shining Armor: Twilight's brother returning from the Army who goes out on dates with Cadance. He & Cadance help Twilight stop Star Swirl. He later attends his sister's funeral.
- Collins Hanks as Spike: Twilight's young brother whose her assistant. He has a crush on Rarity. He later attends Twilight's funeral.
- Lady Gaga as Photo Finish: A photographer who working with Rarity & helps her to stop Star Swirl & later attends Rarity's funeral.
- Natasha Henstridge as Chrysalis: the Former Queen of an Alien Race who tried to invade Earth.
- John De Lancie as Discord: a mad scientist who tried to warp Ponyville. He bcomes friends with Fluttershy, helps her stop Star Swirl & attends her funeral.
- Tony Robbins as Iron Will: a motivational speaker who helps Fluttershy stop Star Swirl & later attends her funeral.
Rainbow Dash's groupEdit
- Jennifer Lawrence as Derpy Hooves: a disabled customer who helps Rainbow Dash stop Star Swirl & later attends her funeral.
- Miley Cyrus as Gilda: a bad girl who makes amends with Rainbow Dash, helps her to Star Swirl & attends her funeral.
Pinkie Pie's GroupEdit
- Ke$ha as DJ Pon-3: Pinkie's Number #1 customer who helps Pinkie stop Star Swirl & plays a funeral song on a DJ station.
- Haley Berry as Zecora: a nurse at the local hospital who helps Pinkie stop Star Swirl & later attends Pinkie's funeral.
- Chris Hensworth as Big McIntosh: Applejack's older brother. He says more than Eeyup & Nnope. He later helps Applejack in stopping Star Swirl & later attends Applejack's funeral.
- Natalie Portman as Cheerilee: Big Mac's girlfriend. She later helps Applejack stop Star Swirl & attends Applejack's funeral.
Cuite Mark CrusadersEdit
- Laura Marano as Apple Bloom: Leader of the Cutie Mark Chronicles & Applejack's sister & assistant. She attends Applejack's funeral.
- Ashley Argota as Sweetie Belle: Rarity's sister & assistant. She attends Rarity's funeral.
- Cymphoniqine Miller as Scootaloo: Rainbow Dash's sister & assistant. She attends Rainbow Dash's funeral.
- Ciara Bravo as Babs Seed: The fourth member of the CMC. She's a bit stronger than the others. She attends Applejack's funeral.
- Miranda Cosgrove as Diamond Tiara: A spoiled brat who later became a Cutie Mark Crusader to stop Star Swirl.
- Jennette McCurdy as Silver Spoon: Diamond Tiara's best friend who did the same thing as Diamond Tiara.